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KMID : 0605619980050020210
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Journal of Korean Society of Biological Psychiatry
1998 Volume.5 No. 2 p.210 ~ p.214
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An Association Study of COMT Gene Polymorphism with Korean Schizophrenics
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1송은숙/1En Sook Song
1채영규/2양병환/3박강규/3오동열/3김길숙/4이유상/4안은숙/5김종원/6최인근/1Young Gyu Chai/2Byung Hwan Yang/3Kang Kyu Park/3Dong Yul Oh/3Gil Sook Kim/4Yu Sang Lee/4Eun Soog An/5Jong Won Kim/6Ihn Geun Choi
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Abstract
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An association study with Korean schizophrenic patients(N=84) and normal
controls(N=87) was performed to find the relationship between catechol-Ο
-methyltransferase(COMT) gene polymorphism and schizophrenia using polymerase chain
reaction-restriction fragment length polymorphism. When we compared the allele and
genotype frequencies of Bg/I COMT gene polymorphism in schizophrenics and normal
controls, there was no significant difference between two groups. Our results do not
support an association between the Bg/I polymorphism of COMT gene and
schizophrenia.
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KEYWORD
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